Newsday.Answers
Daily Newsday Crossword

“Most significant”

The verified answer to the Newsday Crossword clue “Most significant”, with letter-by-letter analysis and the full puzzle context for the Sunday, May 18, 2025 puzzle.

Published · Down · 4 letters

Hints first

Letters 4
First letter M
Last letter N
M ? ? N

A 4-letter down entry from the Sunday puzzle

The Answer

M A I N

The answer to “Most significant” is MAIN

Letters 4
Direction Down
Published May 18, 2025

Letter analysis: the 4-letter answer

Vowels, consonants, and crossword construction notes
Unique 4 of 4 positions
Vowels 2 50% of word
Consonants 2 non-vowels
First letter M starts with

The clue “Most significant” appeared in the Newsday Crossword on Sunday, May 18, 2025 as a down entry. The verified answer is MAIN — a 4-letter word that begins with M and ends with N.

This answer contains 2 vowels and 2 consonants. The Newsday Crossword is published daily by Newsday on Long Island and edited by Stan Newman, whose Saturday Stumper is widely considered one of the toughest mainstream crosswords in print.

Other clues with the answer MAIN

MAIN has been used as the answer for these Newsday Crossword clues
“Most important” Mar 12, 2026 “Most important” Oct 7, 2025 “Foremost” Aug 22, 2025 “__ course (entree)” Jul 14, 2025

More clues from the May 18, 2025 puzzle

Sunday Newsday Crossword
View full puzzle
Jogging pace 4 ℓ · D Tylenol alternative 5 ℓ · D Polite assent 7 ℓ · D Skilled speakers 7 ℓ · D DC winter hours 3 ℓ · D Ewe or sow 3 ℓ · D Kingly title 4 ℓ · D Snake charmer's snake 5 ℓ · D Trait carrier 4 ℓ · D Bible excerpt 7 ℓ · A Trojan War king 5 ℓ · D Back-of-paper section 6 ℓ · A "No ifs, __, or buts" 4 ℓ · D Hourly charge 4 ℓ · D Idealistic hope 5 ℓ · D Thrifty people 6 ℓ · D Buffalo Bill's surname 4 ℓ · A Stared at 5 ℓ · D Dockside platform 4 ℓ · D Meal with matzo 5 ℓ · D

Frequently asked questions about “Most significant”

What is the answer to “Most significant” in the Newsday Crossword?

The verified answer is MAIN — a 4-letter word that appeared as a down entry on Sunday, May 18, 2025.

How many letters is the answer to “Most significant”?

The answer MAIN contains 4 letters.

Was “Most significant” an across or down clue?

This clue ran as a Down entry.

Is this site affiliated with Newsday?

No. This is an independent fan reference site — we are not affiliated with Newsday. The Newsday Crossword is a trademark of its respective owner. We solve and verify each Newsday Crossword puzzle manually before publishing the answer key.

Most significant — Newsday Crossword Clue Answer | Newsday Crossword Answers